What Researchers Did
Researchers investigated the effects of hyperoxia, increased atmospheric pressure, and hyperbaric oxygen on cytokine synthesis in five healthy volunteers.
What They Found
Following hyperbaric oxygen (HBO2) exposure, stimulated lymphocytes released 51% less interferon-gamma (IFN-gamma) compared to pre-exposure levels, a suppression that lasted for 24 hours (P < 0.05). Increased atmospheric pressure alone also significantly inhibited IFN-gamma secretion (P < 0.05), while room air and hyperoxia alone had no significant effect.
Canadian Relevance
This study has no direct Canadian connection or specific relevance to Canadian healthcare policies or patient populations.
Study Limitations
A significant limitation of this study is the very small sample size of only five healthy volunteers.