What Researchers Did
Researchers conducted a scoping review to identify and compare gas-based therapies and evaluate their effectiveness in treating chronic wounds.
What They Found
The review included 54 clinical studies and 45 preclinical studies. While hyperbaric oxygen therapy and topical gas therapies showed some clinical use, their adoption was limited by costs and variable outcomes, whereas novel preclinical formulations like micro- and nanoparticle systems demonstrated improved chronic injury outcomes in models.
Canadian Relevance
This study does not have a direct Canadian connection.
Study Limitations
As a scoping review, this study identified the range of available evidence but did not critically appraise the quality of individual studies or provide a definitive synthesis of treatment efficacy.