HOTFy: randomised clinical trial for hyperbaric... (2026 study) Skip to main content
RCT BMJ Open 2026

HOTFy: randomised clinical trial for hyperbaric oxygen therapy in fibromyalgia

da Mota Neto J, Mendes A, Magalhães Martins A, Teixeira De Landa A, de Oliveira Fraga R, de Souza V, et al., BMJ Open, 2026

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers in Brazil tested whether adding hyperbaric oxygen therapy to standard fibromyalgia care worked better than standard care alone for women with fibromyalgia.

What They Found

This randomized, cross-over trial of 56 women with fibromyalgia found that hyperbaric oxygen therapy added to standard care produced larger improvements than standard care alone. The group given early hyperbaric oxygen therapy had a 31.1% improvement in Fibromyalgia Impact Questionnaire (FIQR-Br) scores, compared with 14.4% in the group that started with standard care alone. Pain scores on the visual analogue scale fell 54.0% in the hyperbaric oxygen group versus 33.5% in the standard-care-only group, and psychopathology scores (EAS-40) dropped 28.4% versus 3.7%. The researchers concluded that hyperbaric oxygen therapy is an effective and well-tolerated adjunct to multimodal fibromyalgia care.

Canadian Relevance

No direct Canadian connection identified; the study was conducted in Brazil.

Study Limitations

The trial was conducted at a single center with only female participants, and the cross-over design means the delayed group's early results reflect standard care alone rather than a separate control group followed for the full study period.

This plain-language summary was generated with AI assistance from the study's abstract; it has not been individually reviewed by a clinician. Always consult the source study and a qualified healthcare professional. See our editorial policy.

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Study Details

Study Type RCT
Category Neurological
Source Pubmed
PubMed ID 42225366
Year Published 2026
Journal BMJ Open
MeSH Terms Humans; Fibromyalgia; Hyperbaric Oxygenation; Female; Middle Aged; Adult; Cross-Over Studies; Brazil; Treatment Outcome; Aged; Pain Measurement; Single-Blind Method; Quality of Life; Young Adult; Adolescent; Diving and Hyperbaric Medicine

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last updated: June 4, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology