Clinical Study Neurotoxicity research 2023

Human Placental Mesenchymal Stem Cell-derived Exosomes in Combination with Hyperbaric Oxygen Synergistically Promote Recovery after Spinal Cord Injury in Rats.

Cheshmi H, Mohammadi H, Akbari M, Nasiry D, Rezapour-Nasrabad R, Bagheri M, et al. — Neurotoxicity research, 2023

View Original on PubMed PMID 37155125

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated the combined effects of human placental mesenchymal stem cell-derived exosomes and hyperbaric oxygen on spinal cord injury recovery in rats.

What They Found

The Exo+HBO group showed significant increases in biochemical factors, IL-10 gene expression, and behavioral functions compared to the SCI group. This combination also considerably reduced MDA levels, apoptotic cells, gliosis, and inflammatory gene expression in the 90 rats studied.

Canadian Relevance

This study has no direct Canadian connection as it was not conducted in Canada nor involved Canadian researchers or participants.

Study Limitations

A primary limitation is that this was an animal study conducted in rats, meaning the findings may not directly translate to human patients.

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Study Details

Study Type	Clinical Study
Category	Neurological
Source	Pubmed
PubMed ID	37155125
Year Published	2023
Journal	Neurotoxicity research
MeSH Terms	Pregnancy; Rats; Humans; Male; Female; Animals; Rats, Sprague-Dawley; Hyperbaric Oxygenation; Exosomes; Placenta; Spinal Cord Injuries; Oxygen; Mesenchymal Stem Cells; Spinal Cord

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Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology