What Researchers Did
Researchers conducted an international multi-centre randomised clinical trial to assess if hyperbaric oxygen treatment (HBOT) in addition to standard care could reduce complications in patients with open tibial fractures.
What They Found
The primary outcome of necrosis or infection within 14 days occurred in 43% of HBOT patients versus 58% of controls (odds ratio 0.55, P = 0.12), which was not statistically significant. However, HBOT significantly reduced tissue necrosis (29% vs 53%, P = 0.01) and late complications (6/53 vs 18/52, P = 0.007), including delayed fracture union. Quality of life measures at one and two years were also superior in HBOT patients, with a mean SF-36 score difference of 2.90 (P = 0.002).
Canadian Relevance
This study did not include Canadian participants or sites, so its direct relevance to the Canadian healthcare context is not explicitly established.
Study Limitations
The study's primary outcome did not reach statistical significance, and the relatively small sample size of 120 patients may limit the generalizability of some findings.