Hyperbaric oxygen (HBO(2)) therapy in thermal burn injury revisited. Pressure does matter. Review. | Canada Hyperbarics Skip to main content
Review Undersea Hyperb Med 2024

Hyperbaric oxygen (HBO(2)) therapy in thermal burn injury revisited. Pressure does matter. Review.

Smolle C, Auinger D, Lindenmann J, Smolle J, Smolle-Juettner F, Kamolz L — Undersea Hyperb Med, 2024

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers reviewed 47 published studies spanning 60 years (32 animal, 11 clinical, 4 volunteer) to identify which treatment factors most predict whether HBOT helps burn patients.

What They Found

Of 94 experiments analyzed, 67.4% showed positive outcomes, 17.9% were mixed, and 14.7% were negative. The only factor that independently predicted a better outcome was treatment pressure: pressures below 3 ATA were significantly associated with better results (p=0.0005). Higher pressures did not improve and may have worsened outcomes.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

The majority of included studies are animal experiments, and the 11 clinical studies had very different designs, making it difficult to draw clear recommendations for human patients.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type Review
Category Thermal Burns
Source Pubmed
PubMed ID 38985148
Year Published 2024
Journal Undersea Hyperb Med
MeSH Terms Hyperbaric Oxygenation; Burns; Humans; Atmospheric Pressure; Animals; Treatment Outcome; Clinical Trials as Topic

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This study relates to Thermal Burns. Read the full clinical overview, the evidence base, and Canadian treatment access for this condition.

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: June 8, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology