What Researchers Did
Researchers described a case of a 60-year-old man with multiple myeloma who developed bisphosphonate-induced osteonecrosis of the jaw and was treated with antibiotics and hyperbaric oxygen therapy.
What They Found
A 60-year-old man with multiple myeloma developed osteonecrosis of the jaw after receiving minodronate for 13 months (total dose 4032 mg) and incadronate (total dose 350 mg). Treatment with clarithromycin, levofloxacin, and hyperbaric oxygen therapy resulted in the complete disappearance of his pain. This was noted as the first reported case of incadronate-induced ONJ.
What This Means for Canadian Patients
Canadian patients with multiple myeloma receiving bisphosphonate therapy should undergo regular dental check-ups for early detection of osteonecrosis of the jaw. If ONJ is detected early, a combination of hyperbaric oxygen and antibiotic therapy may be an effective treatment option.
Canadian Relevance
This study has no direct Canadian connection.
Study Limitations
As a single case report, the findings of this study cannot be generalized to a larger patient population.