RCT La Tunisie medicale 2012

[Hyperbaric oxygen in the treatment of perineal Crohn's disease era of infliximab: a renewal interest?].

Bedioui H, Makni A, Magherbi H, Ben Safta Z — La Tunisie medicale, 2012

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a literature review to assess the efficacy of hyperbaric oxygen therapy (HBO) in treating refractory anal fistulas in Crohn's disease.

What They Found

Among 22 patients from four selected publications, 15 (68.18%) achieved remission with hyperbaric oxygen therapy, a rate comparable to infliximab's 66%. Adverse events were observed in 2 patients (16.6%).

What This Means for Canadian Patients

For Canadian patients with refractory anal fistulas from Crohn's disease, hyperbaric oxygen therapy could be considered a potential treatment option, offering remission rates similar to infliximab. Exploring its combination with existing biotherapies might further improve outcomes.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

The findings are limited by this being a literature review based on a small number of studies (four publications) and a total of only 22 patients.

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Study Details

Study Type	RCT
Category	Uncategorised
Source	Pubmed
PubMed ID	22693080
Year Published	2012
Journal	La Tunisie medicale
MeSH Terms	Adult; Antibodies, Monoclonal; Crohn Disease; Female; Gastrointestinal Agents; Humans; Hyperbaric Oxygenation; Infliximab; Intestinal Fistula; Male; Middle Aged; Perineum; Treatment Failure; Treatment Outcome; Young Adult

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.