Hyperbaric Oxygen Reduces Production of Reactive Oxygen Species in Neutrophils from Polytraumatized Patients Yielding in the Inhibition of p38 MAP Kinase and Downstream Pathways.

What Researchers Did

Researchers investigated how hyperbaric oxygen therapy affected reactive oxygen species production and neutrophil extracellular trap release in neutrophils isolated from severely injured patients and healthy volunteers.

What They Found

Hyperbaric oxygen therapy significantly reduced phorbol-12-myristate-13-acetate induced reactive oxygen species production in neutrophils from both patients and healthy volunteers. A marked decrease in neutrophil extracellular trap release was observed in control cells, with a less pronounced reduction in patient neutrophils, linked to strong downregulation of p38 MAPK activity.

Canadian Relevance

This study has no direct Canadian connection as it was not conducted in Canada or with Canadian participants.

Study Limitations

This study was conducted on isolated cells, indicating a need for further in vivo and clinical trials to confirm these anti-inflammatory effects in living patients.