Clinical Study International journal of molecular sciences 2023

Hyperbaric Oxygen Therapy Alleviates Paclitaxel-Induced Peripheral Neuropathy Involving Suppressing TLR4-MyD88-NF-κB Signaling Pathway.

Wang SH, Huang SH, Hsieh MC, Lu IC, Chou PR, Tai MH, et al. — International journal of molecular sciences, 2023

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated the role of hyperbaric oxygen therapy (HBOT) in alleviating paclitaxel-induced peripheral neuropathy (CIPN) and its connection to the TLR4-MyD88 signaling pathway in a rat model.

What They Found

They found that HBOT and a TLR4 antagonist (TAK-242) significantly alleviated behavioral signs of CIPN, including mechanical allodynia and thermal hyperalgesia, in rats. Immunofluorescence and Western blot analyses showed that HBOT and TAK-242 significantly downregulated the overexpression of TLR4, TRPV1, MyD88, and NF-κB in the spinal cord and dorsal root ganglion.

Canadian Relevance

There is no direct Canadian connection to this study.

Study Limitations

A primary limitation is that this study was conducted in rats, meaning its findings may not directly translate to human patients.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Clinical Study
Category	Neurological
Source	Pubmed
PubMed ID	36982452
Year Published	2023
Journal	International journal of molecular sciences
MeSH Terms	Rats; Animals; Paclitaxel; NF-kappa B; Myeloid Differentiation Factor 88; Lipopolysaccharides; Hyperbaric Oxygenation; Toll-Like Receptor 4; Rats, Sprague-Dawley; Peripheral Nervous System Diseases; Signal Transduction; Antineoplastic Agents; Hyperalgesia; Sulfonamides

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Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology