What Researchers Did
Researchers investigated the effects of hyperbaric oxygen therapy on neuropathic pain in rats with sciatic nerve injury and in patients with idiopathic trigeminal neuralgia.
What They Found
In rats, hyperbaric oxygen therapy (3 ATA pure oxygen) significantly inhibited behavioral signs of neuropathic pain, including thermal hyperalgesia and mechanical allodynia, and altered neurochemical markers. In clinical trials, one course of HBO2 therapy over 10 consecutive days led to rapid, dose-dependent, and long-lasting pain relief in patients with trigeminal neuralgia, evidenced by reduced carbamazepine requirements and lower visual analogue scale scores.
Canadian Relevance
This study has no direct Canadian connection as it was conducted in animals and patients outside of Canada.
Study Limitations
The clinical trial component involved a limited number of patients and would benefit from larger, randomised controlled studies to confirm these findings.