What Researchers Did
Researchers conducted a clinical study with 27 participants to evaluate if hyperbaric oxygen therapy could ameliorate the epithelial-to-mesenchymal transition phenomenon in keloid tissue.
What They Found
In the group receiving hyperbaric oxygen therapy (O group, 9 patients), keloid blood perfusion was significantly reduced. Compared to the control keloid group (K group, 9 patients), the O group showed lower expression of vimentin, fibronectin, VEGF, and HIF-1α, while E-cadherin and ZO-1 expression was significantly higher.
Canadian Relevance
This study was not conducted in Canada and does not have direct Canadian relevance.
Study Limitations
A limitation of this study is its small sample size of only 9 patients per group, which may limit the generalizability of the findings.