RCT Sci Rep 2022

Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial

Hadanny A, Catalogna M, Yaniv S, Stolar O, Rothstein L, Shabi A, et al. — Sci Rep, 2022

View Original on PubMed PMID 36151105

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers conducted a randomised, sham-controlled, double-blind trial to evaluate hyperbaric oxygen therapy (HBOT) in 25 children aged 8-15 with persistent post-concussion syndrome.

What They Found

Following 60 daily sessions, the HBOT group (n=15) showed significant improvements in cognitive function, including general cognitive score (d=0.598, p=0.01) and executive function (d=0.739, p=0.003), compared to the sham group (n=10). They also experienced better emotional scores (p=0.04) and reduced hyperactivity (d=0.244, p=0.03), with clinical outcomes correlating with positive brain MRI changes.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

A limitation of this study is its relatively small sample size, which may affect the generalizability of the findings.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	RCT
Category	Neurological
Source	Pubmed
PubMed ID	36151105
Year Published	2022
Journal	Sci Rep
MeSH Terms	Adolescent; Child; Humans; Brain Concussion; Cognition; Hyperbaric Oxygenation; Post-Concussion Syndrome; Quality of Life

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Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology