Systematic Review Diseases (Basel, Switzerland) 2026

Hyperbaric Oxygen Therapy on Long COVID Symptoms: A Breath of Fresh Air.

Zoccali F, Fratini C, Pennacchia F, Cascone F, de Vincentiis M, Petrella C, et al. — Diseases (Basel, Switzerland), 2026

View Original on PubMed PMID 41745098

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a systematic review to analyze the potential role of hyperbaric oxygen therapy (HBOT) in improving chronic fatigue, cognitive impairments, and neurological disorders associated with Long COVID.

What They Found

The review identified 21 studies published between January 2021 and October 2025, comprising one case report, ten randomised controlled trials, eight systematic reviews, and three studies on molecular mechanisms. These studies suggested that HBOT can improve quality of life, fatigue, cognition, neuropsychiatric symptoms, and cardiopulmonary function in Long COVID patients.

Canadian Relevance

This systematic review did not include any specific Canadian studies or data, therefore, there is no direct Canadian relevance.

Study Limitations

A limitation of this systematic review is the potential heterogeneity and varying quality of the 21 included studies, which comprised diverse methodologies.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Systematic Review
Category	Neurological
Source	Pubmed
PubMed ID	41745098
Year Published	2026
Journal	Diseases (Basel, Switzerland)

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology