Study PLoS One 2014

Hyperbaric oxygen therapy to treat diabetes impaired wound healing in rats

Tuk B, Tong M, Fijneman E, van Neck J — PLoS One, 2014

View Original on PubMed PMID 25329176

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated the effects of hyperbaric oxygen therapy (HBOT) on impaired wound healing in diabetic rats.

What They Found

They found that HBOT significantly improved oxygen saturation of haemoglobin and the quantity of haemoglobin in micro-blood vessels 20 hours after treatment. However, HBOT did not significantly improve wound tissue breaking strength, inflammation, or angiogenesis.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

A key limitation is that this was an animal study, meaning results may not directly translate to human patients.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Study
Category	Wound Care
Source	Pubmed
PubMed ID	25329176
Year Published	2014
Journal	PLoS One
MeSH Terms	Amputation, Surgical; Animals; Blood Vessels; Diabetes Mellitus, Experimental; Diabetic Foot; Hemoglobins; Humans; Hyperbaric Oxygenation; Inflammation; Neovascularization, Physiologic; Rats; Wound Healing

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Ont Health Technol Assess Ser | 2005 Clinical Study ★

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Ontario Medical Advisory Secretariat.

Diabetes Care | 2010 RCT

Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes

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Asian J Surg | 2022 Meta-Analysis

Efficacy of hyperbaric oxygen therapy for diabetic foot ulcers: an updated systematic review and meta-analysis

Zhang Z, Yang C, Jiang M, et al.

J Wound Ostomy Continence Nurs | 2017 RCT

Adjunctive hyperbaric oxygen therapy for healing of chronic diabetic foot ulcers: a randomized controlled trial

Chen CY, Wu RW, Hsu MC, et al.

This study relates to Problem Wounds. Read the full clinical overview, the evidence base, and Canadian treatment access for this condition.

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology