Hyperbaric-oxygen treatment of multiple sclerosis. A randomized, placebo-controlled, double-blind study. | Canada Hyperbarics Skip to main content
RCT The New England journal of medicine 1983

Hyperbaric-oxygen treatment of multiple sclerosis. A randomized, placebo-controlled, double-blind study.

Fischer BH, Marks M, Reich T — The New England journal of medicine, 1983

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a randomized, placebo-controlled, double-blind study on 40 patients with advanced chronic multiple sclerosis to evaluate hyperbaric oxygen treatment.

What They Found

Objective improvement was observed in 12 of 17 (71%) patients receiving hyperbaric oxygen compared to 1 of 20 (5%) patients receiving placebo (P < 0.0001). At one-year follow-up, deterioration occurred in 2 patients (12%) in the oxygen group versus 11 patients (55%) in the placebo group (P < 0.0008).

What This Means for Canadian Patients

This study suggests hyperbaric oxygen may offer a transient benefit for advanced multiple sclerosis, but it is not currently recommended for general use. Patients should discuss all treatment options with their healthcare providers, as further research is needed to confirm long-term efficacy and safety.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

The study's preliminary nature, relatively small sample size, and need for longer follow-up periods limit the generalizability of its findings.

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Study Details

Study Type RCT
Category Neurological
Source Pubmed
PubMed ID 6336824
Year Published 1983
Journal The New England journal of medicine
MeSH Terms Adult; Clinical Trials as Topic; Double-Blind Method; Follow-Up Studies; Humans; Hyperbaric Oxygenation; Middle Aged; Multiple Sclerosis; Placebos; Random Allocation

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.