What Researchers Did
Researchers reported a case of a 69-year-old hemodialysis patient with Graves disease who developed severe bilateral lower limb calciphylaxis (skin and vessel calcification with ulcers), treated with a multidisciplinary protocol including HBOT, skin grafting, and medical therapy.
What They Found
The lesions healed completely with the multidisciplinary protocol, which included daily hemodialysis, sodium thiosulfate, denosumab, HBOT, and skin autograft. The authors note this was the first reported case of calciphylaxis secondary to hyperthyroidism in a dialysis patient.
Canadian Relevance
No direct Canadian connection identified.
Study Limitations
This is a single case report of a rare presentation; no controlled evidence exists for HBOT in calciphylaxis, and outcomes are confounded by multiple simultaneous interventions.