Clinical Study Journal of translational medicine 2025

IL-17 + γδT cell: a new target in hyperbaric oxygen treatment reducing spinal cord injury.

Liu M, Sun Z, Liang F, Yao R, Yang L, Nan D, et al. — Journal of translational medicine, 2025

View Original on PubMed PMID 41107988

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated how hyperbaric oxygen (HBO) treatment reduces spinal cord injury (SCI) by modulating γδT cells, particularly IL-17+γδT cells, using mouse models.

What They Found

Hyperbaric oxygen (HBO) treatment improved locomotor recovery and reduced the proportion of γδT and IL-17+γδT cells, as well as inflammatory cytokines, in wild-type mice with spinal cord injury (SCI). Importantly, these beneficial effects of HBO on locomotor recovery and inflammation were absent in TCRδ-deficient mice, highlighting the critical involvement of γδT cells.

Canadian Relevance

This study does not have a direct Canadian connection as it was not conducted in Canada, nor does it specifically involve Canadian researchers or patient populations.

Study Limitations

A limitation of this study is that the findings are based on mouse models of spinal cord injury, which may not fully translate to human patients.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Clinical Study
Category	Neurological
Source	Pubmed
PubMed ID	41107988
Year Published	2025
Journal	Journal of translational medicine
MeSH Terms	Animals; Hyperbaric Oxygenation; Spinal Cord Injuries; Interleukin-17; STAT3 Transcription Factor; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group F, Member 3; Receptors, Antigen, T-Cell, gamma-delta; Mice; Locomotion; Cytokines; Mice, Knockout; Inflammation; Recovery of Function

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Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology