What Researchers Did
Researchers retrospectively reviewed 60 patients admitted to a Surgical Intensive Care Unit between 1980 and 1989 for severe synergistic soft tissue infections, comparing treatment approaches and mortality rates over two distinct periods.
What They Found
Overall, 14 of 60 patients (23.3%) died from these infections. Mortality decreased from 31.8% (7 of 22 patients) in the first period (1980-1983) to 18.4% (7 of 38 patients) in the second period (1984-1989). This improvement coincided with a shift to broader antibiotic therapy targeting all cultured microorganisms, including streptococci found in 43 patients, and more limited surgical excisions.
Canadian Relevance
This study has no direct Canadian connection.
Study Limitations
A limitation of this study is its retrospective, observational design from a single center without a randomised control group.