Cochrane Review The Cochrane database of systematic reviews 2018 Cochrane

Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery.

Chung C, Bryant A, Brown PD — The Cochrane database of systematic reviews, 2018

View Original on PubMed PMID 29987845

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a systematic review to evaluate the effectiveness of interventions for treating brain radionecrosis in adults.

What They Found

The review aimed to assess interventions for brain radionecrosis, but the provided abstract indicates that establishing effective treatments is challenging due to an unclear pathophysiological mechanism. It also noted anticipated selection bias in non-randomized studies, suggesting a lack of definitive high-quality evidence regarding specific treatment outcomes.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

The study was limited by an anticipated scarcity of randomized controlled trials and the likelihood of selection bias in the included non-randomized studies.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Cochrane Review
Category	Radiation Injury
Source	Pubmed
PubMed ID	29987845
Year Published	2018
Journal	The Cochrane database of systematic reviews
MeSH Terms	Adrenal Cortex Hormones; Adult; Antipyrine; Bevacizumab; Brain; Brain Edema; Drug Therapy, Combination; Edaravone; Gadolinium; Humans; Non-Randomized Controlled Trials as Topic; Radiation Injuries; Radiosurgery; Radiotherapy; Randomized Controlled Trials as Topic

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This study relates to Delayed Radiation Injury. Read the full clinical overview, the evidence base, and Canadian treatment access for this condition.

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology