Is Prompt Hyperbaric Oxygen Adjunctive Therapy Able to Reduce Mortality and Amputation in Management of Necrotizing Soft-Tissue Infection? | Canada Hyperbarics Skip to main content
Study Surg Infect (Larchmt) 2024

Is Prompt Hyperbaric Oxygen Adjunctive Therapy Able to Reduce Mortality and Amputation in Management of Necrotizing Soft-Tissue Infection?

Chiang K, Wang Y, Kang E, Wu Y, Huang C, Lin X, et al. — Surg Infect (Larchmt), 2024

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers analyzed 98 patients with necrotizing soft-tissue infections (flesh-eating disease) treated with surgery, antibiotics, and HBOT to see whether starting HBOT sooner led to better outcomes.

What They Found

Patients who died had significantly longer delays between diagnosis and first HBOT session compared to survivors (p=0.031). Patients who lost limbs also had longer waits before starting HBOT than those who kept their limbs (p=0.031). Earlier HBOT was linked to fewer surgical debridements, shorter hospital and ICU stays, and higher complete wound healing rates.

Canadian Relevance

No direct Canadian connection identified. Necrotizing soft-tissue infection is not a listed OHIP-covered HBOT indication, though it is recognised by Undersea and Hyperbaric Medical Society guidelines.

Study Limitations

This was a retrospective study at a single institution without randomization, so sicker patients may have been delayed for reasons unrelated to HBOT itself.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type Study
Category Infection
Source Pubmed
PubMed ID 39052528
Year Published 2024
Journal Surg Infect (Larchmt)
MeSH Terms Humans; Hyperbaric Oxygenation; Retrospective Studies; Male; Female; Middle Aged; Soft Tissue Infections; Aged; Amputation, Surgical; Adult; Combined Modality Therapy; Treatment Outcome; Debridement; Aged, 80 and over; Fasciitis, Necrotizing

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology