What Researchers Did
Researchers reviewed 50 published cases of Clostridium perfringens septicemia with hemolysis since 1990 to analyze treatment strategies and survival outcomes.
What They Found
They found a high mortality rate of 74% among these 50 patients, with a median time to death of 9.7 hours. Surgical intervention was associated with significantly improved survival (risk ratio 0.23), as was treatment with a combination of penicillin and clindamycin (risk ratio of death 0.46).
Canadian Relevance
This study does not mention any specific Canadian connection or data.
Study Limitations
A limitation of this study is its reliance on a retrospective review of published case reports, which may be subject to reporting bias and heterogeneity.