What Researchers Did
Researchers reviewed how tumour hypoxia acts as a significant barrier to the effectiveness of radiotherapy, chemotherapy, and immunotherapy, and discussed various approaches undertaken to overcome this challenge.
What They Found
They found that tumour hypoxia makes tumours radiation resistant and reduces the efficacy of many chemotherapeutic drugs, also acting as a potent barrier to immunotherapy. While numerous past approaches to reverse hypoxia largely failed due to limited efficacy or adverse side effects, at least two new drugs are currently in clinical trials to address this issue.
Canadian Relevance
This study does not have a direct Canadian connection.
Study Limitations
As a review, this study summarizes existing challenges and potential solutions without presenting new experimental data or definitive clinical outcomes.