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Review Drug Dev Res 2021

Overview of in situ gelling injectable hydrogels for diabetic wounds

Mude L, Sanapalli B, V A, Singh S, Karri V — Drug Dev Res, 2021

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a review to examine the process of diabetic wound healing, current treatments, and the potential of in situ gelling injectable hydrogels.

What They Found

The review highlights that about 25% of patients with diabetes are expected to develop diabetic wounds and may face limb amputations. Current treatments often have limitations like pain, frequent dressing changes, high failure rates, and cost. In situ gelling injectable hydrogels show promise for delivering medications and filling wound defects due to their easy encapsulation and prolonged release.

What This Means for Canadian Patients

Canadian patients with diabetic wounds currently face challenges with existing treatments, including pain and high costs. The development of in situ gelling injectable hydrogels could offer a less invasive and more effective way to deliver medications directly to wounds, potentially improving healing outcomes and reducing the need for frequent dressing changes.

Canadian Relevance

This study is not Canadian. However, it covers diabetic wounds, which are a Health Canada-recognized indication for hyperbaric oxygen therapy (HBOT) when they are diabetic foot ulcers. HBOT is also listed as a Medical Subject Heading (MeSH) term for this review.

Study Limitations

As a review, this study summarizes existing research rather than presenting new clinical data or specific HBOT protocols.

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Study Details

Study Type Review
Category Wound Care
Source Pubmed
PubMed ID 33432634
Year Published 2021
Journal Drug Dev Res
MeSH Terms Bandages; Cell Proliferation; Debridement; Diabetes Complications; Hemostasis; Humans; Hydrogels; Hyperbaric Oxygenation; Infection Control; Inflammation; Injections; Intercellular Signaling Peptides and Proteins; Negative-Pressure Wound Therapy; Skin, Artificial; Wound Healing

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.