Clinical Study Clinical biochemistry 2004

Oxidative stress and antioxidant status in patients undergoing prolonged exposure to hyperbaric oxygen.

Benedetti S, Lamorgese A, Piersantelli M, Pagliarani S, Benvenuti F, Canestrari F — Clinical biochemistry, 2004

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers evaluated oxidative stress and antioxidant defense systems in 12 patients undergoing 15 hyperbaric oxygen treatments for hypoxia-related conditions.

What They Found

They found that repeated hyperbaric oxygen exposures led to a significant accumulation of plasmatic reactive oxygen metabolites (ROM) and malondialdehyde (MDA). After 15 sessions, erythrocyte superoxide dismutase (SOD) and catalase (CAT) activity significantly decreased, while levels of reduced glutathione, alpha-tocopherol, retinol, and glutathione peroxidase remained largely unchanged.

Canadian Relevance

This study has no direct Canadian connection as it was conducted by Italian researchers and did not involve Canadian participants or institutions.

Study Limitations

A key limitation of this study is its small sample size of 12 patients, which may limit the generalizability of the findings.

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Study Details

Study Type	Clinical Study
Category	Uncategorised
Source	Pubmed
PubMed ID	15003734
Year Published	2004
Journal	Clinical biochemistry
MeSH Terms	Antioxidants; Catalase; Erythrocytes; Female; Glutathione Peroxidase; Humans; Hyperbaric Oxygenation; Hypoxia; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.