What Researchers Did
Researchers analyzed serum oxidative stress markers, antioxidant potential, and cytokine levels in two patients with necrotizing soft tissue infection of the lower extremity who received multimodal therapy and had opposite outcomes.
What They Found
Of the two patients treated for necrotizing soft tissue infection, one survived and one died. While serum diacron-reactive oxygen metabolites (d-ROMs) decreased in both cases, the patient who died exhibited persistently high serum levels of interleukin-10, suggesting a potential immunosuppressive status and that d-ROMs may be a prognostic predictor.
Canadian Relevance
This study was conducted in Japan and does not have a direct Canadian connection.
Study Limitations
A significant limitation of this study is its very small sample size, reporting on only two cases.