Pilot Study European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 1996

Physiological implications of hyperbaric oxygen tensions in isolated limb perfusion using melphalan: a pilot study.

Vrouenraets BC, Kroon BB, van de Merwe SA, Klaase JM, Broekmeyer-Reurink MP, van Slooten GW, et al. — European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1996

View Original on PubMed PMID 8738534

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers monitored oxygen levels and pH in tissues and tumours of 12 patients undergoing isolated limb perfusion (ILP) with melphalan, tripling oxygen supply to the perfusate near the end of the procedure.

What They Found

Increasing oxygen supply during isolated limb perfusion (ILP) significantly raised arterial pO2 from 25.5 to 49.4 kPa and subcutaneous pO2 from 10.1 to 16.3 kPa. While muscle pH improved (p = 0.011), tumour pH in 4 patients rose from 7.10 to 7.22, which may negatively impact melphalan's effectiveness as low pH enhances its cytotoxicity.

Canadian Relevance

This pilot study has no direct Canadian connection.

Study Limitations

This was a pilot study with a small sample size, particularly for tumour pH measurements, and the observed tumour pH rise was not statistically significant.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Pilot Study
Category	Uncategorised
Source	Pubmed
PubMed ID	8738534
Year Published	1996
Journal	European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes
MeSH Terms	Adult; Aged; Chemotherapy, Cancer, Regional Perfusion; Extremities; Female; Gases; Humans; Hyperbaric Oxygenation; Lactates; Lactic Acid; Male; Melanoma; Melphalan; Middle Aged; Muscles

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology