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Study Biochem Int 1989

Protective effect of glutathione against oxygen-induced growth inhibition of human diploid fibroblasts

Honda S, Matsuo M — Biochem Int, 1989

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated how a molecule called glutathione protects human cells grown in a lab from growth inhibition caused by high levels of oxygen.

What They Found

They found that increasing glutathione levels in cells, using substances like N-acetylcysteine, prevented the reduction in colony-forming ability caused by hyperbaric oxygen. Conversely, decreasing glutathione levels made cells more susceptible to oxygen-induced growth inhibition. The extent of growth inhibition was directly related to the amount of glutathione within the cells, indicating its crucial protective role.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

This study was conducted on cells in a lab dish, meaning its findings may not directly apply to complex biological systems in living humans.

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Study Details

Study Type Study
Category Ocular / Retinal
Source Pubmed
PubMed ID 2764956
Year Published 1989
Journal Biochem Int
MeSH Terms Buthionine Sulfoximine; Cell Division; Cells, Cultured; Culture Media; Fibroblasts; Glutathione; Humans; Maleates; Methionine Sulfoximine; Oxygen

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