Research | Canada Hyperbarics

Peer-Reviewed Evidence

Research & Clinical Studies

A curated collection of 14,033 landmark studies, systematic reviews, and Canadian research in hyperbaric medicine. Every citation links to its original publication.

Page 1 of 1755 (14,033 studies)

J Craniomaxillofac Surg | 2026 Meta-Analysis

The effectiveness of different treatment methods in the treatment and prevention of medication-related osteonecrosis of the jaw: A systematic review and Bayesian network meta-analysis

Zhang N, Jiang M, Zhang C, Pan Y, Xu R

HBOT ranked second overall in healing rates with an 84.1% success rate, outperforming most non-surgical options and comparable to the best surgical protocols. The analysis included data from multiple randomized and cohort studies.

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J Wound Care | 2026 Meta-Analysis

Hyperbaric oxygen therapy for skin flap transplantation: a meta-analysis

He Z, Sun X, Chen J, Zhang M

HBOT dramatically increased skin flap survival rates, with an odds ratio of 8.57, meaning treated patients were more than 8 times more likely to have their flap survive. Blood oxygen saturation in the flap increased by an average of nearly 20 units, and swelling resolved about 3.8 days faster in HBOT-treated patients. Skin returned to a healthy pink colour about 4.6 days sooner.

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J Clin Med | 2026 Meta-Analysis

Hyperbaric Oxygen Therapy Versus Intravenous Thrombolysis in the Treatment of Central Retinal Artery Occlusion: A Systematic Review and Meta-Analysis

Bakdalieh A, Siddiqui D, Chen D, Yu M

They found that both HBOT and IVT significantly improved vision, with HBOT leading to a -0.57 logMAR improvement and IVT to a -0.53 logMAR improvement. Clinically meaningful vision improvement occurred in 45.8% of patients treated with HBOT and 42.0% of those treated with IVT. Adverse event rates were similar, at 11.3% for HBOT (mainly ear barotrauma) and 10.2% for IVT (mainly bleeding).

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Trials | 2026 RCT

Efficacy of hyperbaric oxygen treatment in veterans and service members with traumatic brain injury-a study protocol for a blinded three-stage group sequential randomized controlled trial

Neumann D, Kumar A, Van Loveren H

This study protocol details a plan to enroll 420 US veterans and service members with chronic mild to moderate TBI. Participants will receive either hyperbaric oxygen therapy at 2.0 Atmospheres Absolute (ATA) or a sham treatment at 1.0 ATA, both for approximately 60 minutes. The main goal is to assess changes in Neurobehavioral Symptom Inventory (NSI) scores, with secondary goals including the number of HBOT sessions needed and the impact on PTSD symptoms.

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Acute Med Surg | 2026 Meta-Analysis

Evaluating the Efficacy of Hyperbaric Oxygen Therapy for Acute Carbon Monoxide Poisoning: A Systematic Review and Meta-Analysis

Fujita M, Todani M, Ajimi Y, Yatabe T, Yokobori S, Araki M, et al.

The analysis of six studies found no significant benefit of hyperbaric oxygen therapy in reducing mortality or improving neurological outcomes for acute carbon monoxide poisoning. A subgroup analysis of treatments at 2.5 ATA or higher also showed no significant advantage over control treatments. The quality of evidence across the included studies was rated as low to very low, with moderate to significant differences between them.

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Support Care Cancer | 2026 Systematic Review

Between hope and uncertainty: the elusive evidence on hyperbaric oxygen therapy and radiotherapy

Cuccia F, Cracchiolo A, Piras A, D'Alessandro S, Carruba G, Mercadante S, et al.

HBOT showed high response rates of 67–100% for hemorrhagic cystitis (bladder bleeding) from pelvic radiation. For breast and head-and-neck cancers, HBOT improved quality of life in retrospective reports but randomized trials did not show consistent benefit. The median treatment was 34.5 sessions at 2.45 atmospheres. HBOT was generally safe, with minor side effects including ear barotrauma and temporary vision changes.

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CNS Neurosci Ther | 2026 Systematic Review

Oxygen Therapy for Intracranial Hemorrhage

Shi Q, Han S, Li X, Guan J, Duan Y, Liao Z, et al.

HBO works by reducing cerebral vasospasm, promoting new blood vessel growth, suppressing inflammation, and improving energy metabolism in the brain. Normobaric oxygen mainly protects the blood-brain barrier and reduces brain swelling. Clinical trials showed improved neurological function recovery and lower mortality in some patients. However, excessive oxygen can have harmful effects, making dose selection critical.

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