Radiotherapy and hyperbaric oxygen in head and neck cancer. Interim report of second clinical trial. | Canada Hyperbarics Skip to main content
Clinical Study Lancet (London, England) 1977

Radiotherapy and hyperbaric oxygen in head and neck cancer. Interim report of second clinical trial.

Henk JM, Smith CW — Lancet (London, England), 1977

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a controlled clinical trial comparing radiotherapy with hyperbaric oxygen to conventional radiotherapy in air for the management of head and neck cancer.

What They Found

They found that survival and local recurrence-free rates were significantly higher in the hyperbaric oxygen group compared to the conventional radiotherapy group. Effects on normal tissue were similar between both groups, and advanced laryngeal carcinoma showed a distinct improvement with a high survival rate without laryngectomy.

What This Means for Canadian Patients

These early findings suggested that hyperbaric oxygen combined with radiotherapy could offer a therapeutic advantage for Canadian patients with head and neck cancer, potentially improving survival and reducing recurrence. For those with advanced laryngeal carcinoma, this approach might offer a chance for high survival rates while avoiding laryngectomy.

Canadian Relevance

This study has no direct Canadian connection as it was conducted elsewhere.

Study Limitations

As an interim report, the study's findings are preliminary and subject to further data collection and analysis.

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Study Details

Study Type Clinical Study
Category Radiation Injury
Source Pubmed
PubMed ID 69192
Year Published 1977
Journal Lancet (London, England)
MeSH Terms Clinical Trials as Topic; Evaluation Studies as Topic; Follow-Up Studies; Head and Neck Neoplasms; Humans; Hyperbaric Oxygenation; Laryngeal Neoplasms; Mouth Neoplasms; Neoplasm Recurrence, Local; Nose Neoplasms; Pharyngeal Neoplasms; Radiotherapy Dosage

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.