RCT Undersea Hyperb Med 2011

Research report: the effects of hyperbaric oxygen preconditioning on myocardial biomarkers of cardioprotection in patients having coronary artery bypass graft surgery

Jeysen Z, Gerard L, Levant G, Cowen M, Cale A, Griffin S — Undersea Hyperb Med, 2011

View Original on PubMed PMID 21721351

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers investigated the effects of hyperbaric oxygen (HBO2) preconditioning on myocardial biomarkers of cardioprotection in 81 patients undergoing coronary artery bypass graft (CABG) surgery.

What They Found

The study found no significant differences in myocardial eNOS and HSP72 quantities between the HBO2 (n=41) and control (n=40) groups. However, in the HBO2 group, these biomarkers increased following ischaemia and reperfusion, suggesting potential endogenous cardioprotection.

Canadian Relevance

This study was not conducted in Canada and therefore does not have direct Canadian relevance.

Study Limitations

A limitation is that the study focused on exploratory secondary endpoints and specific biomarkers, which may not fully represent overall cardioprotection.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	RCT
Category	Neurological
Source	Pubmed
PubMed ID	21721351
Year Published	2011
Journal	Undersea Hyperb Med
MeSH Terms	Adult; Aged; Aged, 80 and over; Biomarkers; Biopsy; Coronary Artery Bypass; HSP72 Heat-Shock Proteins; Heart Atria; Humans; Hyperbaric Oxygenation; Ischemic Preconditioning, Myocardial; Middle Aged; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase Type III; Prospective Studies; Research Report; Young Adult

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Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology