Study Aesthetic Plast Surg 2020

Study of the Effect of Hyperbaric Oxygen Therapy on the Viability of Dorsal Cutaneous Flaps in Tobacco-Exposed Rats

Camargo C, Pfann R, Kubrusly M, Silva M, Guimarães E, Leite M, et al. — Aesthetic Plast Surg, 2020

View Original on PubMed PMID 32193614

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated how hyperbaric oxygen therapy (HBOT) affected the survival of skin flaps in rats that had been exposed to tobacco smoke for two months.

What They Found

The HBOT group, which received seven daily sessions of HBOT at 2 ATA for 90 minutes, showed a significantly increased viable flap area (84%) compared to the control group (47%). HBOT also led to an increase in appendage units and angiogenesis density, and a decrease in iNOS levels, though it did not alter VEGF-a levels.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

A limitation of this study is that it was conducted on rats, meaning the findings may not directly apply to human patients.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

Was this summary helpful?

Study Details

Study Type	Study
Category	Wound Care
Source	Pubmed
PubMed ID	32193614
Year Published	2020
Journal	Aesthetic Plast Surg
MeSH Terms	Animals; Humans; Hyperbaric Oxygenation; Rats; Rats, Wistar; Surgical Flaps; Vascular Endothelial Growth Factor A; Nicotiana

Related Research

Cochrane | 2015 Systematic Review

Hyperbaric oxygen therapy for chronic wounds

Kranke P, Bennett MH, Martyn-St James M, et al.

Ont Health Technol Assess Ser | 2005 Clinical Study ★

Hyperbaric oxygen therapy for non-healing ulcers in diabetes mellitus: an evidence-based analysis

Ontario Medical Advisory Secretariat.

Diabetes Care | 2010 RCT

Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes

Löndahl M, Katzman P, Nilsson A, et al.

Asian J Surg | 2022 Meta-Analysis

Efficacy of hyperbaric oxygen therapy for diabetic foot ulcers: an updated systematic review and meta-analysis

Zhang Z, Yang C, Jiang M, et al.

J Wound Ostomy Continence Nurs | 2017 RCT

Adjunctive hyperbaric oxygen therapy for healing of chronic diabetic foot ulcers: a randomized controlled trial

Chen CY, Wu RW, Hsu MC, et al.

This study relates to Problem Wounds. Read the full clinical overview, the evidence base, and Canadian treatment access for this condition.

See all Wound Care research

View on PubMed Back to Research Library

Find a Canadian Clinic Treating Wound Care

Browse verified hyperbaric facilities across Canada.

View Canadian Facilities

Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 16, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology