The awakening effect of hyperbaric oxygen therapy combined with systematic auditory stimulation in comatose patients with craniocerebral injury and its influence on serum biomarkers | Canada Hyperbarics Skip to main content
Study Front Neurol 2026

The awakening effect of hyperbaric oxygen therapy combined with systematic auditory stimulation in comatose patients with craniocerebral injury and its influence on serum biomarkers

Rong J, Guan Y, Ge C, Liu X, Lu G, Cao S, et al. — Front Neurol, 2026

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers studied if combining hyperbaric oxygen therapy (HBOT) and systematic auditory stimulation (SAS) with standard care could help comatose patients with severe traumatic brain injury (sTBI) recover consciousness faster.

What They Found

Patients receiving HBOT at 2.0 atmospheres absolute (ATA) for 60 minutes per session, five sessions per week for four weeks, plus SAS, showed significantly better consciousness scores by Day 28. For example, their average Full Outline of UnResponsiveness (FOUR) score improved to 12.1 compared to 9.3 in the control group, and Glasgow Coma Scale (GCS) scores improved to 11.3 versus 9.1 (all p < 0.001).

Canadian Relevance

No direct Canadian connection identified. Severe traumatic brain injury and coma are not Health Canada-recognized indications for hyperbaric oxygen therapy.

Study Limitations

This single study's findings may not apply to all patients with severe traumatic brain injury due to variations in patient characteristics or treatment protocols.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type Study
Category Neurological
Source Pubmed
PubMed ID 42256554
Year Published 2026
Journal Front Neurol

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: June 12, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology