What Researchers Did
Researchers continuously recorded conventional and quantitative electroencephalograms (EEGs) in 23 subjects during 30-minute exposures to 2.8 bar pure oxygen to monitor for signs of toxicity.
What They Found
Among 23 subjects who did not show signs of toxicity, EEG changes were minor and not considered indicative of an adverse effect of hyperbaric oxygen on the brain.
In one subject who experienced a generalized tonic-clonic seizure, pre-convulsive EEG changes were detected but were too insignificant for practical monitoring purposes and did not clearly herald clinical signs.
Canadian Relevance
This study has no direct Canadian connection as it was not conducted in Canada nor involved Canadian participants or institutions.
Study Limitations
A key limitation is that pre-convulsive EEG changes were too subtle to be practically useful for monitoring and predicting seizures during hyperbaric oxygen exposure.