What Researchers Did
Researchers explored the effect of hyperbaric oxygen and air on tissue-engineered cartilage formation from human adipose-derived stem cells seeded on gelatin/polycaprolactone biocomposites.
What They Found
Histological analyses showed no significant increase in chondrocyte cell number, but the 1,9-dimethylmethylene blue assay demonstrated a marked increase in glycosaminoglycans syntheses compared to the control group. Chondrogenic-specific gene expression of SOX9, aggrecan, and COL2A1 were also compared, leading to the conclusion that 2.5 atmosphere absolute oxygen and air may aid cartilage tissue engineering development.
Canadian Relevance
This study does not have a direct Canadian connection.
Study Limitations
The researchers acknowledged that the study had specific limitations that should be considered.