The Impact of Hyperbaric Oxygen Therapy on Functional and Structural Plasticity in Rats With Spinal Cord Injury | Canada Hyperbarics Skip to main content
Study Brain Behav 2024

The Impact of Hyperbaric Oxygen Therapy on Functional and Structural Plasticity in Rats With Spinal Cord Injury

Yang X, Wu Z, Lai H, Chen L, Cao D, Liu F — Brain Behav, 2024

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

This prospective randomized controlled animal trial investigated the impact of hyperbaric oxygen therapy (HBOT) on brain neuronal activity and neuromotor function in rats with spinal cord injury (SCI).

What They Found

Following SCI, rats exhibited reduced regional homogeneity (ReHo) values in specific brain regions, which were reversed after HBOT. HBOT also increased functional connectivity strength between the motor cortex and other brain areas, including the left secondary motor cortex and bilateral primary somatosensory cortex, and improved BBB scale scores, indicating enhanced neuromotor function.

Canadian Relevance

This study has no direct Canadian connection as it was conducted in rats and the authors are not affiliated with Canadian institutions.

Study Limitations

A primary limitation of this study is its reliance on an animal model, meaning the findings may not directly translate to human patients with spinal cord injury.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type Study
Category Neurological
Source Pubmed
PubMed ID 39663753
Year Published 2024
Journal Brain Behav
MeSH Terms Animals; Hyperbaric Oxygenation; Female; Spinal Cord Injuries; Rats, Sprague-Dawley; Magnetic Resonance Imaging; Rats; Neuronal Plasticity; Disease Models, Animal; Brain; Motor Cortex

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Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology