The mechanism of optic nerve damage in experimental acute intraocular pressure elevation | Canada Hyperbarics Skip to main content
Study Invest Ophthalmol Vis Sci 1980

The mechanism of optic nerve damage in experimental acute intraocular pressure elevation

Quigley H, Flower R, Addicks E, McLeod D — Invest Ophthalmol Vis Sci, 1980

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers elevated eye pressure in 32 primate eyes and studied nerve cell transport, comparing animals breathing room air to those breathing 100% oxygen at 3 atmospheres pressure in a hyperbaric chamber.

What They Found

Both groups, including the 32 primate eyes exposed to hyperbaric oxygen, experienced a blockage of nerve cell transport at the optic nerve head. Despite significant increases in arterial oxygen levels in the hyperbarically oxygenated animals, this treatment did not prevent the transport blockade. This suggests that a lack of oxygen is not the primary cause of acute nerve damage from high eye pressure, but rather mechanical compression.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

This study was conducted on primate eyes in 1980, and its findings may not directly translate to human conditions or current understanding.

Was this summary helpful?

Study Details

Study Type Study
Category Ocular / Retinal
Source Pubmed
PubMed ID 6154668
Year Published 1980
Journal Invest Ophthalmol Vis Sci
MeSH Terms Animals; Autoradiography; Axonal Transport; Blood Gas Analysis; Female; Glaucoma; Haplorhini; Hyperbaric Oxygenation; Intraocular Pressure; Macaca fascicularis; Male; Optic Disk; Optic Nerve; Retina

Cite This Study

Share

Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.