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RCT Pharmacotherapy 2000

The psychometric and cardiac effects of dimenhydrinate in the hyperbaric environment

Taylor D, O'Toole K, Auble T, Ryan C, Sherman D — Pharmacotherapy, 2000

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers studied how dimenhydrinate (Gravol) affects thinking and heart function in divers at different pressures to assess its safety in diving environments.

What They Found

Dimenhydrinate significantly lowered mental flexibility scores (p0.05). However, two subjects experienced abnormal heartbeats after taking the drug. Increased pressure alone significantly decreased verbal memory test scores (p=0.001) and mean heart rate (p<0.001).

What This Means for Canadian Patients

For Canadian patients who are divers, taking dimenhydrinate could impair their mental flexibility, which is crucial for safety underwater. This effect, combined with pressure's impact on memory, highlights potential risks for divers using this medication.

Canadian Relevance

While this study was not conducted in Canada, its findings are relevant to Canadian divers. The use of hyperbaric environments for diving safety, especially concerning medications like dimenhydrinate, relates to Health Canada-recognized indications such as decompression sickness.

Study Limitations

This study focused on a specific group of active divers in a monoplace chamber, so the findings may not apply to all individuals or other hyperbaric settings.

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Study Details

Study Type RCT
Category Neurological
Source Pubmed
PubMed ID 10999496
Year Published 2000
Journal Pharmacotherapy
MeSH Terms Aged; Analysis of Variance; Atmosphere Exposure Chambers; Atmospheric Pressure; Cross-Over Studies; Dimenhydrinate; Diving; Double-Blind Method; Female; Heart Rate; Histamine H1 Antagonists; Humans; Male; Memory; Mental Processes; Middle Aged; Psychometrics; Trail Making Test; Ventricular Premature Complexes

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.