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Systematic Review Regional anesthesia and pain medicine 2023 Canadian

The role of hyperbaric oxygen therapy in the management of perioperative peripheral nerve injury: a scoping review of the literature.

Brenna CT, Khan S, Katznelson R, Brull R, Regional anesthesia and pain medicine, 2023

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers reviewed existing studies on hyperbaric oxygen therapy as an add-on treatment for nerve injuries that occur during or after surgery.

What They Found

This scoping review analyzed 51 studies (40 animal, 11 human) on hyperbaric oxygen therapy for peripheral nerve injury linked to surgery or anesthesia, finding it was reported as beneficial in 88% (45 of 51) of all included studies, including 82% of human studies and 90% of animal studies. Benefits included improved nerve regeneration and/or faster recovery time. No major adverse events were reported. Treatment protocols varied widely across studies and were used at both early and late points after the injury occurred.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

This is a scoping review with a narrative synthesis rather than a systematic review with formal quality assessment, most included studies were in animals rather than humans, and treatment protocols were highly inconsistent across studies, making it hard to identify one optimal approach.

This plain-language summary was generated with AI assistance from the study's abstract; it has not been individually reviewed by a clinician. Always consult the source study and a qualified healthcare professional. See our editorial policy.

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Study Details

Study Type Systematic Review
Category Neurological
Source Pubmed
PubMed ID 36418044
Year Published 2023
Journal Regional anesthesia and pain medicine
MeSH Terms Animals; Humans; Hyperbaric Oxygenation; Peripheral Nerve Injuries; Prospective Studies; Oxygen; Ischemia

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last updated: April 1, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology