Therapeutic Efficacy of Hyperbaric Oxygen in Central Retinal Artery Occlusion: A Systematic Review and Meta-Analysis | Canada Hyperbarics Skip to main content
Meta-Analysis J Clin Med 2026

Therapeutic Efficacy of Hyperbaric Oxygen in Central Retinal Artery Occlusion: A Systematic Review and Meta-Analysis

ALBalawi H, Magliyah M, Alali N, Alshehri M, Alhewiti A, Almarek F, et al. — J Clin Med, 2026

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers conducted a systematic review and meta-analysis of twelve studies to evaluate how well hyperbaric oxygen therapy (HBOT) works and its safety for treating central retinal artery occlusion (CRAO).

What They Found

The analysis showed that HBOT was beneficial for CRAO, with a pooled odds ratio of 0.47 (95% CI: 0.26-0.87; p = 0.02). Visual improvement was greater when HBOT started within 12 hours of CRAO onset, while delayed treatment showed less consistent benefits. Importantly, the rates of adverse events were similar between HBOT and non-HBOT groups (OR = 0.70; 95% CI: 0.43-1.16; p = 0.17).

What This Means for Canadian Patients

For Canadian patients experiencing central retinal artery occlusion, this study suggests that hyperbaric oxygen therapy could be a promising treatment option. The findings highlight the importance of receiving HBOT quickly, ideally within 12 hours of symptoms, to achieve the best visual recovery and potentially improve vision outcomes.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

A limitation of this meta-analysis was the substantial variability found among the included studies, which could influence the overall findings.

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Study Details

Study Type Meta-Analysis
Category Ocular / Retinal
Source Pubmed
PubMed ID 42123263
Year Published 2026
Journal J Clin Med

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.