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Clinical Study Stereotactic and functional neurosurgery 1998

Treatment of cerebral radionecrosis by hyperbaric oxygen therapy.

Leber KA, Eder HG, Kovac H, Anegg U, Pendl G — Stereotactic and functional neurosurgery, 1998

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a preliminary study on two patients with cerebral radionecrosis following Gamma Knife radiosurgery to evaluate the efficacy of hyperbaric oxygen therapy.

What They Found

Both patients responded well to hyperbaric oxygen therapy, with one lesion disappearing completely and the other significantly reduced in size. This occurred after 40 sessions of breathing 100% oxygen at 2.5 atmospheres absolute, without the use of adjuvant steroids.

Canadian Relevance

This study has no direct Canadian connection as it was not conducted in Canada, nor did it involve Canadian researchers or patients.

Study Limitations

The primary limitation of this study is its very small sample size of only two patients, making the findings preliminary and requiring further confirmation.

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Study Details

Study Type Clinical Study
Category Radiation Injury
Source Pubmed
PubMed ID 9782255
Year Published 1998
Journal Stereotactic and functional neurosurgery
MeSH Terms Adult; Brain; Female; Humans; Hyperbaric Oxygenation; Intracranial Arteriovenous Malformations; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Necrosis; Radiation Injuries; Radiosurgery; Treatment Outcome

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This study relates to Delayed Radiation Injury. Read the full clinical overview, the evidence base, and Canadian treatment access for this condition.

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology