Meta-Analysis Medicine (Baltimore) 2018

Treatment with normobaric or hyperbaric oxygen and its effect on neuropsychometric dysfunction after carbon monoxide poisoning: A systematic review and meta-analysis of randomized controlled trials

Lin C, Su W, Chen Y, Feng P, Shen W, Ong J, et al. — Medicine (Baltimore), 2018

View Original on PubMed PMID 30278526

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers conducted a systematic review and meta-analysis of 6 randomised controlled trials comparing HBOT versus normobaric oxygen for neuropsychological dysfunction after CO poisoning.

What They Found

Patients treated with HBOT had lower rates of headache, memory impairment, difficulty concentrating, and disturbed sleep compared to those treated with normobaric oxygen alone, though the differences did not individually reach statistical significance. Two sessions of HBOT showed no advantage over one session.

Canadian Relevance

Carbon monoxide poisoning is an OHIP-covered indication for HBOT in Ontario.

Study Limitations

This meta-analysis pooled only 6 trials with varying protocols and patient severity; heterogeneity between studies limits the strength of conclusions.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Meta-Analysis
Category	Neurological
Source	Pubmed
PubMed ID	30278526
Year Published	2018
Journal	Medicine (Baltimore)
MeSH Terms	Carbon Monoxide Poisoning; Carboxyhemoglobin; Disease Progression; Humans; Hyperbaric Oxygenation; Memory Disorders; Nervous System Diseases; Outcome Assessment, Health Care; Oxygen Inhalation Therapy; Randomized Controlled Trials as Topic; Sleep Wake Disorders; Treatment Outcome

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Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology