What Researchers Did
Researchers investigated the effect of hyperbaric oxygen therapy on methylguanidine synthesis in vivo by measuring serum and urinary methylguanidine and creatinine in patients undergoing the treatment.
What They Found
The urinary excretion rate of methylguanidine (MG/creatinine ratio) significantly increased after hyperbaric oxygen therapy in all four patient groups. The ratio of urine MG/urine creatinine/serum creatinine, an index of MG synthesis, also increased, suggesting active oxygen plays a role in MG synthesis in vivo.
Canadian Relevance
This study has no direct Canadian connection.
Study Limitations
A limitation of this study is the lack of a control group not undergoing hyperbaric oxygen therapy to compare baseline methylguanidine levels.