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Clinical Trial Anasthesiol Intensivmed Notfallmed Schmerzther 2000

Ventilation according to the "open lung" concept of multiple trauma patients

Knothe C, Huber T, Hiltl P, Regel G, Bayeff-Filloff M — Anasthesiol Intensivmed Notfallmed Schmerzther, 2000

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

The researchers studied 18 patients with severe multiple trauma and chest injuries to see how a specific "open lung" ventilation method affected their lung function, other organs, and infection rates.

What They Found

They found that the "open lung" ventilation approach provided early and sufficient oxygenation and ventilation for these patients. This method helped prevent lung damage from pressure or volume, and no negative side effects were observed on other organs like the liver or kidneys. The infection rate was low, with therapeutic antibiotics needed for less than half of the patients' ICU stay.

Canadian Relevance

No direct Canadian connection identified. This study is not about a Health Canada-recognised hyperbaric oxygen therapy indication.

Study Limitations

The study involved a small number of patients (18) from a single center, which limits the generalizability of the findings.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type Clinical Trial
Category Infection
Source Pubmed
PubMed ID 10858840
Year Published 2000
Journal Anasthesiol Intensivmed Notfallmed Schmerzther
MeSH Terms Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Hyperbaric Oxygenation; Infections; Lung; Male; Middle Aged; Multiple Trauma; Positive-Pressure Respiration; Respiration, Artificial; Respiratory Mechanics; Thoracic Injuries

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 17, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology