Whole blood pro-inflammatory cytokines and adhesion molecules post-lipopolysaccharides exposure in hyperbaric conditions. | Canada Hyperbarics Skip to main content
Clinical Study European cytokine network 2004

Whole blood pro-inflammatory cytokines and adhesion molecules post-lipopolysaccharides exposure in hyperbaric conditions.

Fildissis G, Venetsanou K, Myrianthefs P, Karatzas S, Zidianakis V, Baltopoulos G — European cytokine network, 2004

View Original on PubMed PMID 15542446
Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated the effect of hyperbaric oxygen (HBO) on pro-inflammatory cytokine release and adhesion molecule regulation after lipopolysaccharide (LPS) stimulation in 16 healthy individuals.

What They Found

The study found that hyperbaric oxygen (HBO) exposure enhanced the effect of LPS stimulation, leading to increased production of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-8). It also caused a reduction in sICAM-1 levels, while sVCAM levels remained unchanged in the 16 healthy participants.

Canadian Relevance

This study has no direct Canadian connection as it was not conducted in Canada, nor did it involve Canadian participants or institutions.

Study Limitations

A limitation of this study is its small sample size of 16 healthy individuals and its in vitro nature, which may not fully reflect complex physiological responses in patients.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type Clinical Study
Category Infection
Source Pubmed
PubMed ID 15542446
Year Published 2004
Journal European cytokine network
MeSH Terms Adult; Cell Adhesion Molecules; Cytokines; Enzyme-Linked Immunosorbent Assay; Humans; Hyperbaric Oxygenation; Lipopolysaccharides; Middle Aged

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology