What Researchers Did
Researchers systematically reviewed medical databases from 1960 to 2007 to understand how wound healing affects acquired subglottic stenosis and to evaluate pharmacologic treatments.
What They Found
The review found that most potential modulating agents for subglottic stenosis were poorly investigated. While steroids, antibiotics, and antireflux medications were thoroughly studied, conflicting data exist regarding their effectiveness. Current evidence offers some support for using antibiotics, steroids, and antireflux treatment, but mitomycin remains an unproven treatment.
Canadian Relevance
No direct Canadian connection identified.
Study Limitations
A key limitation is the lack of robust investigation for many potential treatments and the conflicting evidence for those that were thoroughly studied.