What Researchers Did
Researchers conducted a comprehensive literature review across multiple databases to describe the clinical profile, investigational approach, and management techniques for various presentations of skull base osteomyelitis.
What They Found
The review of 153 articles found that early and aggressive culture-guided long-term intravenous broad-spectrum antibiotic therapy reduces post-infection complications. For widespread soft tissue involvement, early aggressive surgical removal of infectious sequestra, preferably with Hyperbaric Oxygen therapy, is associated with better prognosis, fewer neurological sequelae, and lower mortality rates.
Canadian Relevance
This study has no direct Canadian connection as none of the authors are identified as Canadian, nor was the research conducted in Canada.
Study Limitations
As a literature review, this study's findings are limited by the quality and heterogeneity of the included articles and the potential for publication bias.