Non-pharmacologic therapies for sleep disturbances after traumatic brain injury: a systematic review and meta-analysis | Canada Hyperbarics Skip to main content
Meta-Analysis Brain Impair 2026

Non-pharmacologic therapies for sleep disturbances after traumatic brain injury: a systematic review and meta-analysis

Loong S, Qazi Z, Jora I, Zrodlowski T, Blakenship J, Lad S — Brain Impair, 2026

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers conducted a systematic review and meta-analysis of randomised controlled trials to evaluate non-pharmacologic therapies for sleep disturbances after traumatic brain injury.

What They Found

Cognitive behavioural therapy (CBT) significantly improved sleep quality (PSQI by -3.44), insomnia severity (ISI by -2.23 at 6-8 weeks and -0.91 at 12-16 weeks), and daytime sleepiness (ESS by -1.45 at 16 weeks). Only the improvement in sleep quality met a clinically important difference. For hyperbaric oxygen therapy (HBOT), blue-wavelength light therapy, and repetitive transcranial magnetic stimulation, the evidence was very low, and HBOT showed a higher risk of mild ear barotrauma compared to sham (relative risk: 2.66).

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

The study's main limitation for hyperbaric oxygen therapy, blue-wavelength light therapy, and repetitive transcranial magnetic stimulation was the very low quality of evidence due to small sample sizes and varied study designs.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

Was this summary helpful?

Study Details

Study Type Meta-Analysis
Category Neurological
Source Pubmed
PubMed ID 42086508
Year Published 2026
Journal Brain Impair
MeSH Terms Humans; Brain Injuries, Traumatic; Sleep Wake Disorders; Cognitive Behavioral Therapy; Transcranial Magnetic Stimulation; Hyperbaric Oxygenation; Sleep Initiation and Maintenance Disorders; Phototherapy

Cite This Study

Share
Discuss with a qualified healthcare professional. Then: Review Coverage Guide View Recognised Conditions

Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: May 8, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology