RCT Journal of neurosurgery 2010

A prospective, randomized clinical trial to compare the effect of hyperbaric to normobaric hyperoxia on cerebral metabolism, intracranial pressure, and oxygen toxicity in severe traumatic brain injury.

Rockswold SB, Rockswold GL, Zaun DA, Zhang X, Cerra CE, Bergman TA, et al. — Journal of neurosurgery, 2010

View Original on PubMed PMID 19852540

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a prospective randomised clinical trial with 69 severe traumatic brain injury patients to compare hyperbaric oxygen, normobaric hyperoxia, and standard care.

What They Found

Brain tissue oxygen levels significantly increased during treatment in both the hyperbaric oxygen (223 ± 29 mm Hg) and normobaric hyperoxia (86 ± 12 mm Hg) groups compared to the control group (p < 0.0001). This suggests that both hyperoxic interventions effectively delivered supraphysiological oxygen to the brain in severe TBI patients.

Canadian Relevance

This study was not conducted in Canada and does not have a direct Canadian connection.

Study Limitations

This study primarily focused on short-term physiological changes in brain tissue oxygenation, and the abstract does not detail long-term clinical outcomes or potential adverse effects.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	RCT
Category	Neurological
Source	Pubmed
PubMed ID	19852540
Year Published	2010
Journal	Journal of neurosurgery
MeSH Terms	Biomarkers; Brain Injuries; Bronchoalveolar Lavage; Cerebrovascular Circulation; Drug Administration Schedule; Humans; Hyperbaric Oxygenation; Hyperoxia; Intracranial Hypertension; Mitochondria; Oxygen; Oxygen Consumption; Prospective Studies; Severity of Illness Index

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology