Cohort Study Undersea Hyperb Med 2014

A retrospective cohort study of lidocaine in divers with neurological decompression illness

Weenink R, Hollmann M, Zomervrucht A, van Ooij P, van Hulst R — Undersea Hyperb Med, 2014

View Original on PubMed PMID 24851549

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a retrospective cohort study comparing 14 patients who received adjuvant intravenous lidocaine for neurological decompression illness with 21 patients who did not, all treated with hyperbaric oxygen therapy.

What They Found

The study found no significant positive or negative effect of lidocaine on patient outcome, with a relative risk for objective neurological signs at follow-up in the lidocaine group of 1.8 (95% CI 0.2-16). Both groups had comparable injury severity scores (lidocaine 2.7 +/- 1.7, control 2.0 +/- 1.6) and similar numbers of hyperbaric oxygen sessions (lidocaine 2.7 +/- 2.3, control 2.0 +/- 1.0).

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

The study was under-powered to draw definitive conclusions regarding the effect of lidocaine in neurological decompression illness.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Cohort Study
Category	Neurological
Source	Pubmed
PubMed ID	24851549
Year Published	2014
Journal	Undersea Hyperb Med
MeSH Terms	Adult; Case-Control Studies; Chemotherapy, Adjuvant; Decompression Sickness; Embolism, Air; Female; High Pressure Neurological Syndrome; Humans; Hyperbaric Oxygenation; Injections, Intravenous; Intracranial Embolism; Lidocaine; Male; Middle Aged; Neuroprotective Agents; Retrospective Studies; Severity of Illness Index; Young Adult

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Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology